Mary Case is a graduate of the University of Missouri-Columbia and the Saint Louis University School of Medicine. She completed her residency training in pathology at the Saint Louis University Health Sciences Center and is board certified in anatomical pathology, neuropathology, and forensic pathology.

In addition to being a professor of pathology and codirector of the Division of Forensic Pathology at St. Louis University Health Sciences Center, Dr. Case serves as chief medical examiner for the cities of St. Louis and St. Charles, and Jefferson and Franklin Counties. Her primary practice is forensic pathology, and her areas of special interest are children's injuries and head trauma.